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Cloned monkeys shed light on circadian disorders

By ZHOU WENTING | China Daily | Updated: 2019-01-24 07:59
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A staff member feeds cloned monkeys with circadian rhythm disorders at the Institute of Neuroscience of Chinese Academy of Sciences in Shanghai, east China, Jan 22, 2019. China has cloned five monkeys from a gene-edited macaque with circadian rhythm disorders, the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research. Scientists made the announcement Thursday, with two articles published in National Science Review, a top Chinese journal in English. The cloned monkeys were born in Shanghai at Institute of Neuroscience of Chinese Academy of Sciences. [Photo/Xinhua]

Two articles about the studies were to be published by China-based international journal National Science Review on Thursday.

An increasing number of people are suffering from circadian disorders in modern society, with frequent overtime work, staying up late and traveling across time zones. The researchers said people without a regular daily schedule are prone to problems in their mental health and interpersonal relations.

Most studies on circadian rhythm disorders so far have been conduced on mice, which are not the best animal model because mice are nocturnal and their brain structures and functions are unlike humans, the researchers said.

"The cloned monkeys solved the problems of the long breeding cycle and small number of babies born to macaques. These monkeys, with their unified genetic background, are well-suited to be animal models," Poo said.

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